Markers of T Cell Exhaustion and Senescence and Their Relationship to Plasma TGF-β Levels in Treated HIV+ Immune Non-responders

Autor:	Carey L. Shive, Michael L. Freeman, Souheil-Antoine Younes, Corinne M. Kowal, David H. Canaday, Benigno Rodriguez, Michael M. Lederman, Donald D. Anthony
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	HIV+ immune non-responders inflammation senescence exhaustion T regulatory cells TGF-β Immunologic diseases. Allergy RC581-607
Zdroj:	Frontiers in Immunology, Vol 12 (2021)
Druh dokumentu:	article
ISSN:	1664-3224 84481900
DOI:	10.3389/fimmu.2021.638010
Popis:	Background: Immune non-responders (INR) are HIV+, ART-controlled (>2 yrs) people who fail to reconstitute their CD4 T cell numbers. Systemic inflammation and markers of T cell senescence and exhaustion are observed in INR. This study aims to investigate T cell senescence and exhaustion and their possible association with soluble immune mediators and to understand the immune profile of HIV-infected INR. Selected participants were
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/877d6a41a162433c84481900387900cf Zobrazit plný text záznamu View record in DOAJ