Enhanced circulating levels of CD3 cells-derived extracellular vesicles in different forms of pulmonary hypertension

Autor: Djuro Kosanovic, Ujjwal Deo, Henning Gall, Balachandar Selvakumar, Susanne Herold, Astrid Weiss, Aleksandar Petrovic, Akylbek Sydykov, Hossein Ardeschir Ghofrani, Ralph Theo Schermuly
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Pulmonary Circulation, Vol 9 (2019)
Druh dokumentu: article
ISSN: 2045-8940
20458940
DOI: 10.1177/2045894019864357
Popis: It has been shown previously that increased circulating endothelial cells-derived extracellular vesicles represent an important pathological attribute of pulmonary hypertension. Although it is a well-known fact that inflammatory cells may also release extracellular vesicles, and pulmonary hypertension is a disease associated with abnormal inflammation, there is no profound knowledge with regard to the role of inflammatory cells-derived extracellular vesicles. Therefore, our study demonstrated that circulating levels of extracellular vesicles derived from T-cells are enhanced in various pulmonary hypertension forms and that endothelial cells-derived extracellular vesicles may have distinctive profiles in different clinical subgroups of pulmonary hypertension, which still remains as a poorly treatable and life-threatening disorder.
Databáze: Directory of Open Access Journals
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