| Autor: |
Sevde Baydemir, Ayse Filiz Gokmen Karasu, Nurhan Sahin, Seval Turna, Aysegül Yabacı Tak, Caglar Cetin, Gulsah Ilhan |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Van Tıp Dergisi, Vol 31, Iss 1, Pp 5-12 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2587-0351 |
| DOI: |
10.5505/vmj.2024.54872 |
| Popis: |
INTRODUCTION: Purpose: To determine the antiadhesive effects of bemiparine sodium compared to hyaluronic acid based jel on a standard adhesion formation model of rat uterine horn. METHODS: Twenty non-pregnant female Sprague Dawley rats weighing 180-220 g were used to inflict a standardized model of adhesion formation on a rat uterine horn. The rats were randomized into four groups. Control group (group 1), bemiparin group (group 2), HA (hyaluronic acid) group (group 3) and bemiparin+hyaluronic acid group (group 4). Ten standardized lesions were inflicted using bipolar cauterization. The uterine horns of 20 rats were evaluated macroscopically, microscopically and with immunohistochemistry. For macroscopic evaluation; 'adhesion type', 'adhesion tenacity', 'extent of adhesions' and 'total macroscopic adhesion score' were determined. For microscopic evaluation; inflammation and fibrosis formation was evaluated. Immunohistochemistry scoring was performed utilizing VEGF and TGF-β1 markers. RESULTS: Results: Macroscopic adhesion scores, including 'adhesion type', 'adhesion extent' and 'total macroscopic adhesion score' in the bemiparin+HA group (group4) was significantly lower than those in the control group (group1) and group HA (group3) (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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