| Autor: |
Guangying Lu, Yiyuan Miao, Jianchao Zhao, Xin Chen, Yanxiong Ke |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Separations, Vol 10, Iss 1, p 11 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2297-8739 |
| DOI: |
10.3390/separations10010011 |
| Popis: |
In this study, brush type and polymer type stationary phases were prepared based on (S)-N-(1-phenylethyl) acrylamide, and the polymeric stationary phase demonstrated superior chiral recognition ability. The two polymeric stationary phases were synthesized by two strategies, one was the “grafting from” method, which obtained polymer CSP by initiating monomer polymerization on the surface of 3-methacrylatepropyl silica gel, and the other was “grafting to”, which fixed the copolymer of (S)-N-(1-phenylethyl) acrylamide and trimethoxysilylpropyl methacrylate on silica gel. A comparison of these two bonding modes revealed that the stationary phase produced by “grafting to” had higher chiral recognition ability. Further improvement can be achieved by the end-capping of silanol groups with trimethylchlorosilane to reduce non-enantioselective retention caused by residual silanol groups and improve the peak shape of enantiomers. Chiral separation in subcritical fluid chromatography was also studied. Similar enantioselectivity results with higher resolution were observed due to the improvement of peak shape. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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