False Positive Findings of [18F]PSMA-1007 PET/CT in Patients After Radical Prostatectomy with Undetectable Serum PSA Levels

Autor: Marina Orevi, Simona Ben-Haim, Galith Abourbeh, Alexandre Chicheportiche, Eyal Mishani, Vladimir Yutkin, Ofer N. Gofrit
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Frontiers in Surgery, Vol 9 (2022)
Druh dokumentu: article
ISSN: 2296-875X
DOI: 10.3389/fsurg.2022.943760
Popis: BackgroundPET-CT using prostate-specific membrane antigen (PSMA)-targeting radiopharmaceuticals labeled with 68Ga or 18F has emerged as the most sensitive staging tool in prostate cancer (PC). Nonetheless, the occurrence of false positive (FP) findings presents a major concern of this approach. In this prospective study, we investigated the frequency and pattern of false-positive findings of [18F]PSMA-1007 PET/CT in patients after radical prostatectomy with undetectable serum PSA levels. Any discrete non-physiological accumulation of [18F]PSMA-1007 in this population is by definition FP.MethodsSeventeen men after radical prostatectomy, whose serum PSA levels were
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