Neuropathic pain in primary knee osteoarthritis patients: correlation with physical function, quality of life, disease severity, and serum beta nerve growth factor levels

Autor: Shereen R. Kamel, Radwa S. Ibrahim, Hend M. Moens, Rania M. Mohammed
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Egyptian Rheumatology and Rehabilitation, Vol 48, Iss 1, Pp 1-9 (2021)
Druh dokumentu: article
ISSN: 1110-161X
2090-3235
DOI: 10.1186/s43166-021-00086-x
Popis: Abstract Background Neuropathic mechanisms are thought to play a role in knee osteoarthritis (KOA) pain. Neuropathic pain questionnaires can promote diagnosis of a neuropathic component. Thus, we aimed to assess the frequency of neuropathic pain in primary KOA patients (using clinical questionnaires) and to investigate its correlation with socio-demographic factors, physical function, quality of life, disease severity, and serum beta nerve growth factor (β-NGF) levels. Results Seventy primary KOA patients were included. Neuropathic pain was detected in 52.9% of patients based on Douleur Neuropathique en 4 Questions (DN4) questionnaire and in 38.6% of patients based on Leeds assessment neuropathic pain symptoms and signs questionnaire (LANSS). Serum β-NGF levels were significantly higher in KOA patients than controls (P
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