The median effective concentration of ropivacaine for ultrasound-guided anterior iliopsoas muscle space block in the elderly undergoing hip surgery: a dose-finding study

Autor: Peng Ma, Rui Zeng, Jiang Peng, Juan Zhu, Zhaojun Jing, Yu Han
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: PeerJ, Vol 12, p e17970 (2024)
Druh dokumentu: article
ISSN: 2167-8359
DOI: 10.7717/peerj.17970
Popis: Background In order to improve perioperative pain and reduce the adverse outcome of severe pain in elderly hip fractures, anterior iliopsoas muscle space block (AIMSB) can be used clinically to reduce pain. The aim of the study is to investigate the 50% effective concentration (EC50) of ropivacaine for ultrasound-guided anterior iliopsoas space block in elderly with hip fracture. Methods A total of 27 patients were enrolled with aged ≥65 years, American society of Anesthesiologists (ASA) physical status classification II–III and undergoing Total Hip Arthroplasty (THA). We measured the EC50 using Dixon’s up-and-down method. Ultrasound-guided AIMSB was performed preoperatively with an initial concentration of 0.2% in the first patient. After a successful or unsuccessful postoperative analgesia, the concentration of local anesthetic was decreased or increased 0.05%, respectively in the next patient. The successful block effect was defined as no sensation to pinprick in the area with femoral nerve, obturator nerve, and lateral femoral cutaneous nerve in 30 min. Meanwhile, the EC50 of ropivacaine was determined by using linear model, linear-logarithmic model, probit regression model, and centered isotonic regression. Results A total of 12 patients (48%) had a successful block. All patients with a successful block had a postoperative visual analog scale score of
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