| Autor: |
Catharina Lavebratt, Elisabeth Dungner, Johan Hoffstedt |
| Jazyk: |
angličtina |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
Journal of Lipid Research, Vol 46, Iss 10, Pp 2278-2281 (2005) |
| Druh dokumentu: |
article |
| ISSN: |
0022-2275 |
| DOI: |
10.1194/jlr.M500201-JLR200 |
| Popis: |
The alpha2 Heremans-Schmid glycoprotein (AHSG) gene is implicated in the regulation of body fat and insulin sensitivity. The Met/Met genotype of the common single-nucleotide polymorphism (SNP), rs4917, in the AHSG gene has been shown to be associated with reduced plasma levels as well as lower body fat. Here, we studied the association of this variation with subcutaneous adipocyte lipolysis. Ninety-three obese and nonobese healthy men were genotyped for Thr230Met, and subcutaneous adipose tissue biopsies were analyzed for lipolysis characteristics. The Met/Met genotype was associated with a marked increase of 1.5 log units in the lipolytic sensitivity to the β2-adrenoceptor agonist terbutaline (P = 0.0008) as compared with the Thr/Thr and Thr/Met genotypes. This corresponds to an approximately 35-fold increase in β2-adrenoceptor function. The genotype effect was independent of body mass index and waist circumference. In contrast, lipolytic sensitivity to both the β1-adrenoceptor agonist dobutamine (P = 0.25) and the α2A-adrenoceptor agonist clonidine (P = 0.54) was unaffected by the Thr230Met variation. Moreover, no difference in either maximal stimulation or inhibition of lipolysis was found between genotypes.We conclude that a common variation (Thr230Met) in the AHSG gene is associated with a marked increase in β2-adrenoceptor sensitivity in subcutaneous fat cells, which may be of importance in body weight regulation. |
| Databáze: |
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