Effect of anti-epileptic drugs on first trimester screening test results

Autor: Canan Unal, Atakan Tanacan, Erdem Fadiloglu, Oytun Portakal, M. Sinan Beksac
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Taiwanese Journal of Obstetrics & Gynecology, Vol 59, Iss 6, Pp 835-837 (2020)
Druh dokumentu: article
ISSN: 1028-4559
DOI: 10.1016/j.tjog.2020.09.009
Popis: Objective: To evaluate first trimester screening test parameters in epileptic patients using anti-epileptic drugs. Materials and methods: We retrospectively evaluated first trimester screening test results of 23 epileptic pregnant women using anti-epileptic drugs with a control group consisting of 92 healthy pregnancies. The anti-epileptic drugs used in this study were carbamazepine, levatiracetam, valproic acid and lamotrigine. Single drug or multi-drug regimens were used according to the clinical conditions. Patients with any known chronic or acute disease and drug usage were excluded from the study. Comparisons were performed via Mann–Whitney U test. Results: First trimester screening test biochemical markers were compared and maternal serum PAPP-A MoM values were found to be similar in study and control groups while β-hCG MoM values were significantly higher in pregnancies using epileptic drugs (p: 0,737 and p
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