Photoreceptor Impairment and Restoration on Optical Coherence Tomographic Image
| Autor: | Yoshinori Mitamura, Sayaka Mitamura-Aizawa, Takashi Katome, Takeshi Naito, Akira Hagiwara, Ken Kumagai, Shuichi Yamamoto |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Journal of Ophthalmology, Vol 2013 (2013) |
| Druh dokumentu: | article |
| ISSN: | 2090-004X 2090-0058 |
| DOI: | 10.1155/2013/518170 |
| Popis: | With recent development of spectral-domain optical coherence tomography (SD-OCT), the pathological changes of retina can be observed in much greater detail. SD-OCT clearly delineates three highly reflective lines in the outer retina, which are external limiting membrane (ELM), photoreceptor inner and outer segment (IS/OS) junction, and cone outer segment tips (COST) in order from inside. These lines can serve as hallmarks for the evaluation of photoreceptor condition. In retinitis pigmentosa (RP) leading to photoreceptor degeneration, the ELM, IS/OS, and COST lines are shortened with the progression of the disease. In addition, shortening of the ELM, IS/OS and COST lines is significantly associated with each other. The line length is longest in the ELM, followed by the IS/OS, and COST, suggesting that retinal layer becomes disorganized first at the COST, followed by the IS/OS and finally the ELM. This finding is consistent with the previous report that the earliest histopathological change in RP is a shortening of the photoreceptor outer segments. On the other hand, retinal layer becomes restored first at the ELM, followed by the IS/OS and finally the COST after macular hole surgery. There may be a directionality of photoreceptor impairment or restoration on optical coherence tomographic image. |
| Databáze: | Directory of Open Access Journals |
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