Muscle-invasive urothelial bladder cancer: an update on systemic therapy
| Autor: | Hayley Knollman, J. Luke Godwin, Rishi Jain, Yu-Ning Wong, Elizabeth R. Plimack, Daniel M. Geynisman |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Therapeutic Advances in Urology, Vol 7 (2015) |
| Druh dokumentu: | article |
| ISSN: | 1756-2872 1756-2880 17562872 |
| DOI: | 10.1177/1756287215607418 |
| Popis: | Urothelial carcinoma is a common malignancy that carries a poor prognosis when the disease includes muscle invasion. Metastatic urothelial carcinoma is almost uniformly fatal. The evidence behind treatment options in the neoadjuvant, adjuvant and metastatic settings are discussed in this manuscript, with a focused review of standard and investigational cytotoxic, targeted, and immunotherapy approaches. We have focused especially on neoadjuvant cisplatin-based therapy (supported by level one evidence) and on novel immunotherapy agents such as checkpoint inhibitors, which have shown great promise in early clinical studies. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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