Epidermal Growth Factor Receptor Gene in Non-Small-Cell Lung Cancer: The Importance of Promoter Polymorphism Investigation

Autor: Vladimir Jurišić, Jasmina Obradovic, Sonja Pavlović, Nataša Djordjevic
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Analytical Cellular Pathology, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 2210-7177
2210-7185
DOI: 10.1155/2018/6192187
Popis: Recently, epidermal growth factor receptor (EGFR) was a key molecule in investigation of lung cancer, and it was a target for a new therapeutic strategy, based on molecular analyses. In this review, we have summarized some issues considering the role of EGFR in lung cancer, its coding gene, and its promoter gene polymorphisms (SNPs) -216G/T and -191C/A in non-small-cell lung cancer (NSCLC). The position of the SNPs indicates their significant role in EGFR regulation. The accumulation of knowledge regarding SNPs lately suggests their significant and important role in the onset of carcinogenesis, the prediction of the onset of metastases, the response to therapy with TKI inhibitors, and the onset of toxic effects of the applied therapy. Based on this, we suggest further studies of the relationship of clinical significance to SNPs in patients with lung tumors.
Databáze: Directory of Open Access Journals
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