Hearing impairment following surgically repaired congenital heart disease in children: a prospective study

Autor: Ekarat Nitiyarom, Kanthong Thongyai, Kanittha Sakjirapapong, Chodchanok Vijarnsorn, Yarlanphol Thirakulnanchai, Prakul Chanthong, Paweena Chungsomprasong, Supaluck Kanjanauthai, Ploy Thammasate, Thita Pacharapakornpong, Eakkarat Boonchom, Kritvikrom Durongpisitkul, Jarupim Soongswang, Suvajana Atipas, Teerapong Tocharoenchok, Kriangkrai Tantiwongkosri, Thaworn Subtaweesin
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMJ Paediatrics Open, Vol 8, Iss 1 (2024)
Druh dokumentu: article
ISSN: 2399-9772
DOI: 10.1136/bmjpo-2024-002938
Popis: Objectives To determine the prevalence of sensorineural hearing loss (SNHL) in children who underwent congenital cardiac surgery (CCS) by using a pre- and postoperative hearing test, a conventional audiometry, an extended high-frequency audiometry (HFA) or auditory steady-state response (ASSR), and distortion-product otoacoustic emissions (DPOAE).Study design This prospective study enrolled children with CCS in Siriraj Hospital, Thailand, between 2019 and 2023. Conventional audiometry including HFA or ASSR and DPOAE were performed pre- and postoperatively. The patients with bilateral abnormal hearing loss or an incomplete examination were excluded. Collected data included: demographics, cardiac surgery and ototoxic medication. Prevalence of SNHL by conventional audiometry and subclinical hearing impairment by HFA or DPOAE were ascertained, and risks were analysed.Results Ninety-eight patients were eligible for the study. The median age (IQR) was 5.3 (1.5–9.6) years. Fifteen patients (15.3%) had univentricular hearts. The preoperative audiologic test was performed 1 day prior to the CCS. The postoperative test was performed at a median of 4.4 (IQR: 2.7–8.0) months postoperatively. Preoperative unilateral hearing impairments were reported in 17 patients (17.3%). Postoperatively, four patients (4.1%) showed significantly abnormal audiogram (> 25 dB) or 15 dB shift at 250–8000 Hz consistent to a new SNHL. Subclinical hearing impairment by HFA was affected in 10 patients (10.2%). Thirty-three patients (33.6%) had abnormal DPOAE exclusively. Therefore, new SNHL, including subclinical hearing loss, revealed a prevalence of ototoxicity up to 47.9%. Age
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