Progesterone/Oestradiol ratio can better predict intracytoplasmic sperm injection outcomes than absolute progesterone level

Autor: Reda S Hussein, Ihab Elnashar, Hisham A Abou-Taleb, Yulian Zhao, Ahmed M Abdelmagied, Ahmed M Abbas, Osama S Abdalmageed, Ahmed A Abdelaleem, Tarek A Farghaly, Ahmed A Youssef, Esraa Badran, Mostafa N Ibrahim, Ahmed F Amin
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Human Reproductive Sciences, Vol 14, Iss 1, Pp 28-35 (2021)
Druh dokumentu: article
ISSN: 0974-1208
1998-4766
DOI: 10.4103/jhrs.JHRS_57_20
Popis: Background: Several parameters were proposed to predict the impact of premature luteinization on intracytoplasmic sperm injection (ICSI) outcomes such as isolated progesterone (P) level, progesterone to oocyte ratio, and progesterone/estradiol ratio (P/E2). Aim: The aim of this study is to compare the predictive value of P/E2 ratio and isolated P level on the ovulation triggering day for pregnancy outcomes in fresh GnRH antagonist ICSI cycles. Settings and Design: A retrospective cohort study conducted in a university-affiliated in vitro fertilization center between January 2017 and April 2019. Methods: The study included women who underwent their first- or second-ranked GnRH antagonist ICSI cycles with day-3 embryo transfer. P/E2 ratio was calculated as (P [ng/mL] × 1000)/E2 (pg/mL). Cutoff values of ≥1.5 ng/ml for high P (HP) and ≥0.55 for HP/E2 ratio were chosen based on the literature. Statistical Analysis: A receiver operating curve was performed to detect the predictability of serum P/E2 and P for the ongoing pregnancy rate. First, patients were divided according to either P level (low P < 1.5 ng/mL and HP ≥1.5 ng/mL) or P/E2 ratio (low P/E2
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