Effects of Konjaku Flour on the Gut Microbiota of Obese Patients

Autor: Yu Li, Yongbo Kang, Yuhui Du, Minghui Chen, Liqiong Guo, Xinwei Huang, Tingting Li, Shi Chen, Fan Yang, Fubing Yu, Jingan Hong, Xiangyang Kong
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Druh dokumentu: article
ISSN: 2235-2988
DOI: 10.3389/fcimb.2022.771748
Popis: ObjectiveGut microbiota have been thought to play a role in the emergence of obesity and metabolic disorders, thus dietary fiber may be an effective strategy for the management of obesity by modulating the gut microbiota. The aim of the present study was to investigate the effects of konjaku flour (KF) supplementation on treating obesity and regulating intestinal microbiota in obese adults.MethodsIn a 5-week, randomized, double-blind, place-controlled trial, sixty-nine obese volunteers aged 25 to 35 with body mass index ≥28 kg/m2 were randomly assigned to receive KF or placebo (lotus root starch). Obesity index, blood parameters, and gut microbiota were analyzed.ResultsKF remarkably reduced the body mass index (BMI), fat mass, percentage body fat (PBF), serum triglyceride (TG), glycated hemoglobin A1c (HbA1c), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels in the patients (p
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