Elevated serum levels of methylglyoxal are associated with impaired liver function in patients with liver cirrhosis

Autor: Maurice Michel, Cornelius Hess, Leonard Kaps, Wolfgang M. Kremer, Max Hilscher, Peter R. Galle, Markus Moehler, Jörn M. Schattenberg, Marcus-Alexander Wörns, Christian Labenz, Michael Nagel
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-021-00119-7
Popis: Abstract Methylglyoxal (MGO) is a highly reactive dicarbonyl species that forms advanced glycation end products (AGEs). The binding of these AGEs to their receptor (RAGE) causes and sustains severe inflammation. Systemic inflammation is postulated to be a major driver in the progression of liver cirrhosis. However, the role of circulating MGO levels in liver cirrhosis remains unknown. In this study, we investigated the serum levels of two dicarbonyl species, MGO and glyoxal (GO) using tandem mass spectrometry (HPLC–MS/MS) and evaluated their association with disease severity. A total of 51 inpatients and outpatients with liver cirrhosis of mixed etiology and different disease stages were included. Elevated MGO levels were seen in an advanced stage of liver cirrhosis (p
Databáze: Directory of Open Access Journals
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