Microbial osteoporosis: The interplay between the gut microbiota and bones via host metabolism and immunity

Autor: Lishan Li, Shitao Rao, Yanzhen Cheng, Xiaoyun Zhuo, Caihong Deng, Ningning Xu, Hua Zhang, Li Yang
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: MicrobiologyOpen, Vol 8, Iss 8, Pp n/a-n/a (2019)
Druh dokumentu: article
ISSN: 2045-8827
DOI: 10.1002/mbo3.810
Popis: Abstract The complex relationship between intestinal microbiota and host is a novel field in recent years. A large number of studies are being conducted on the relationship between intestinal microbiota and bone metabolism. Bone metabolism consisted of bone absorption and formation exists in the whole process of human growth and development. The nutrient components, inflammatory factors, and hormone environment play important roles in bone metabolism. Recently, intestinal microbiota has been found to influence bone metabolism via influencing the host metabolism, immune function, and hormone secretion. Here, we searched relevant literature on Pubmed and reviewed the effect of intestinal microbiota on bone metabolism through the three aspects, which may provide new ideas and targets for the clinical treatment of osteoporosis.
Databáze: Directory of Open Access Journals