Loss of EphA7 Expression in Basal Cell Carcinoma by Hypermethylation of CpG Islands in the Promoter Region

Autor:	Jie Liu, Na Yu, Xiao Feng, Yan He, Kang Lv, Haiping Zhu, Jiandong Wang
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Zdroj:	Analytical Cellular Pathology, Vol 2022 (2022)
Druh dokumentu:	article
ISSN:	2210-7185
DOI:	10.1155/2022/4220786
Popis:	Basal cell carcinoma (BCC) is the most common malignancy worldwide, with increasing incidence. BCCs present low mortality but high morbidity, and its pathogenesis remains unclear. Eph receptors have been implicated in tumorigenesis. EphA7 plays a role as a tumor suppressor in certain cancers. We checked EphA7 expression levels and methylation status in a set of BCCs, benign skin diseases, and compound nevus tissue samples using immunohistochemistry. EphA7 protein was positively expressed in normal basal cells, benign skin diseases, and compound nevus cells, but lost in areas of BCC tissues. We detected hypermethylation in BCC tissue samples with reduced expression of EphA7. There is a significant relationship between the expression level of EphA7 receptor protein and the methylation status of CpG islands in the EphA7 promoter region (P
Databáze:	Directory of Open Access Journals
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