| Autor: |
Katarina Zeder, Teresa Sassmann, Vasile Foris, Philipp Douschan, Horst Olschewski, Gabor Kovacs |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
International Journal of Cardiology Congenital Heart Disease, Vol 17, Iss , Pp 100519- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2666-6685 |
| DOI: |
10.1016/j.ijcchd.2024.100519 |
| Popis: |
Rationale: Severe pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) is currently defined by an elevated mean pulmonary arterial pressure and strongly elevated pulmonary vascular resistance >5 wood units. Clinically, these patients show a male predominance, and usually present with very severe dyspnea, severe hypoxemia, strongly decreased exercise capacity and poor prognosis, even though the clinical picture is frequently associated with less severe airflow obstruction. Explanted lung samples of patients with COPD and severe PH show severe remodeling of small pulmonary arterioles, predominantly in the intima and media of the vessels. In this concise review, we discuss the clinical and histopathological evidence of severe PH in COPD. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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