Allele Frequencies of HLA Class-I Loci in the Normal Iranian Population
| Autor: | Andisheh Ghashghaie, Kamran Alimoghaddam, Mohammad Reza Ostadali, Hamid-o-allah Ghaffari, L Khansari, M Sadraee, E Mirrasekhian, Iranna Mohyedin, F Raoofi, Z Noori, H Yaghmaian, H Eshaghi, Ardeshir Ghavamzadeh |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | International Journal of Hematology-Oncology and Stem Cell Research, Vol 3, Iss 2, Pp 18-20 (2009) |
| Druh dokumentu: | article |
| ISSN: | 2008-3009 2008-2207 |
| Popis: | "nIntroduction: Human Leukocyte Antigen (HLA) genes are the most polymorphic loci in the human genome. They predict the outcome of transplantation by detecting self from non-self antigens. The best use of HLA typing is to find a HLA-match donor for BMT candidate patients. Evidence suggests that matching unrelated donors and recipients for HLA-A, -B and -DRB1 loci is a prediction for an improved outcome. "nMethods and materials: HLA-A and -B of six hundred Iranian cord blood samples were typed by PCR-SSP method and the frequency of loci were estimated. "nResults: The most frequent alleles were A*02(18.16), A*24(16.41), B*35(21.66) and B*51(13.35), respectively. "nDiscussion: Our HLA typing data show similarity between neighbor and related countries and Caucasians. Identifying HLA alleles helps to find suitable donors for patients in need of hematopoietic stem cell transplantation. |
| Databáze: | Directory of Open Access Journals |
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