| Autor: |
Manuel Rodrigues de Sousa, Sara Martins, Neuza Soares, Lígia Coelho, Tiago Neto, Rui Balhau |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Advances in Oral and Maxillofacial Surgery, Vol 5, Iss , Pp 100236- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2667-1476 |
| DOI: |
10.1016/j.adoms.2021.100236 |
| Popis: |
Background: The purpose of this study was to systematically review all cases of acinic cell carcinoma (AcCC) associated with paraneoplastic ectopic ACTH-dependent Cushing's syndrome (CS-EAS). Methods: An electronic search was performed October 2020, using PubMed/MEDLINE and Science Direct databases. Results: The search resulted in a total of 9 cases. AcCC was only found in the parotid, and primary treatment included surgical excision (n = 9), neck dissection (n = 6) and radiotherapy (n = 6). High-grade transformation was reported in 2 cases. CS-EAS was diagnosed 6 months after AcCC treatment in 4 patients. Clinical features observed included hypokalemia (n = 9), myopathy (n = 7), edema and hypertension (n = 6), as well as cushingoid fat distribuition (n = 5). In 6 cases, disease-associated death was reported. Conclusions: Clinicians should be aware of this aggressive presentation of AcCC and should consider this diagnosis in patients with Cushingoid signs and symptoms. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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