The immunological phenotype of rituximab-sensitive chronic graft-versus-host disease: a phase II study
| Autor: | Suzanne van Dorp, Henrike Resemann, Liane te Boome, Floor Pietersma, Debbie van Baarle, Frits Gmelig-Meyling, Roel de Weger, Eefke Petersen, Monique Minnema, Henk Lokhorst, Saskia Ebeling, Scott J.P. Beijn, Edward F. Knol, Marijke van Dijk, Ellen Meijer, Jürgen Kuball |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Haematologica, Vol 96, Iss 9 (2011) |
| Druh dokumentu: | article |
| ISSN: | 0390-6078 1592-8721 |
| DOI: | 10.3324/haematol.2011.041814 |
| Popis: | Chronic graft-versus-host disease is the major long-term complication after allogeneic stem cell transplantation with a suboptimal response rate to current treatments. Therefore, clinical efficacy and changes in lymphocyte subsets before and after rituximab treatment were evaluated in a prospective phase II study in patients with steroid-refractory chronic graft-versus-host disease. Overall response rate was 61%. Only responding patients were found to have increased B-cell numbers prior to treatment. B cells had a naïve-antigen-presenting phenotype and were mainly CD5 negative or had a low CD5 expression. Normal B-cell homeostasis was reestablished in responding patients one year after ritxumab treatment and associated with a significant decline in skin-infiltrating CD8+ T cells, suggesting that host B cells play a role in maintaining pathological CD8+ T-cell responses. Imbalances in B-cell homeostasis could be used to identify patients a priori with a higher chance of response to rituximab treatment (Eudra-CT 2008-004125-42). |
| Databáze: | Directory of Open Access Journals |
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