Hematological Alterations after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy

Autor: Maria Consuelo Pintado, Inmaculada Lasa Unzúe, Remedios Gómez Sanz, Manuel Diez Alonso, Miguel A. Ortega, Melchor Álvarez de Mon, Emilio Nevado Losada, Alberto Gutierrez Calvo
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Clinical Medicine, Vol 12, Iss 13, p 4323 (2023)
Druh dokumentu: article
ISSN: 2077-0383
DOI: 10.3390/jcm12134323
Popis: Background: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have benefits for survival in some cancers with peritoneal metastasis. Hematologic toxicity described rate is 2 to 38%. Methods: Patients admitted to an intensive care unit (ICU) after CRS and HIPEC over 78 months. The data recorded were demographic characteristics, the severity of illness, complete blood samples, the type of cancer and extension, HIPEC drug and temperature, ICU and hospital stay and mortality, bleeding, and the need for transfusion of blood products. Results: Of the 96 patients included, 77.1% presented hematological complications: 8.3% leukopenia (3 leucocytes), 66.7% anemia (hemoglobin < 10 mg/dL), and 22.9% coagulopathy (INR < 1.5, or/and aPTT < 45 s, or/and platelet count < 100,000/mm3, or/and
Databáze: Directory of Open Access Journals
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