| Autor: |
Ricard Cervera, Marcello Govoni, Alberto Cauli, Matteo Piga, Alberto Floris, Mattia Congia, Alessandro Mathieu, Florenzo Iannone, George Bertsias, Luca Cantarini, Vincenzo Venerito, Giuseppe Lopalco, Antonio Vitale, Piergiorgio Neri, Carlos Vasconcelos, Raquel Faria, Gerard Espinosa, Elisabetta Chessa, Ignasi Rodriguez Pinto, Andrea Lo Monaco, GIOVANNI CIANCIO, Luísa Serpa Pinto, Nikolaos Kougkas, Ida Orlando, Vittorio Pirani, Ernestina Santos, João Correia, Ana Martins Silva, Monica Muntoni, Nestor Avgoustidis, Roberto Rios Garcés, Giulio Guerrini, Gema Lledó Ibáñez, Piero Mascia |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
RMD Open, Vol 6, Iss 2 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2056-5933 |
| DOI: |
10.1136/rmdopen-2020-001192 |
| Popis: |
Objective To develop and validate the evidence-based and consensus-based Behçet’s Syndrome Overall Damage Index (BODI).Methods Starting from 120 literature-retrieved preliminary items, the BODI underwent multiple Delphi rounds with an international multidisciplinary panel consisting of rheumatologists, internists, ophthalmologists, neurologists, and patient delegates until consensus was reached on the final content. The BODI was validated in a cross-sectional multicentre cohort of 228 patients with Behçet’s syndrome (BS) through the study of (a) correlation between BODI and Vasculitis Damage Index (VDI) and (b) correlation between BODI and disease activity measures (ie, Behçet’s Disease Current Activity Form (BDCAF), Physician Global Assessment (PGA), Patient Global Assessment (PtGA)), c) content and face validity and (d) feasibility.Results The final BODI consists of 4 overarching principles and 46 unweighted-items grouped into 9 organ domains. It showed good to excellent reliability, with a mean Cohen’s k of 0.84 (95% CI 0.78 to 0.90) and a mean intra-class correlation coefficient of 0.88 (95% CI 0.80 to 0.95). Overall, 128 (56.1%) patients had a BODI score ≥1, with a median score of 1.0 (range 0–14). The BODI significantly correlated with the VDI (r=0.693, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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