Cutaneous Syncytial Myoepithelioma with Positive CD34 Immunohistochemical Staining: An Unusual Tumor and a Challenging Diagnosis

Autor:	Cesare Ariasi, Carola Romanò, Iacopo Ghini, Gaetano Licata, Luca Rubelli, Grazia Linda Artelli, Piergiacomo Calzavara-Pinton, Mariachiara Arisi
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	cutaneous syncytial myoepithelioma skin neoplasms EWSR1 CD34 Dermatology RL1-803
Zdroj:	Dermatopathology, Vol 10, Iss 3, Pp 259-265 (2023)
Druh dokumentu:	article
ISSN:	10030034 2296-3529
DOI:	10.3390/dermatopathology10030034
Popis:	Cutaneous syncytial myoepithelioma (CSM) is a rare type of cutaneous neoplasm that typically presents as a solitary and well-circumscribed nodule on the skin. It predominantly occurs on the upper and lower extremities of adult patients. Immunohistochemically, CSM is characterized by the co-expression of smooth muscle and epithelial markers. Fluorescence in situ hybridization (FISH) targeting the EWSR1 gene rearrangement is an important diagnostic tool for CSM. In our case report, we found the focal positivity for CD34, which has never been previously observed; this was mostly confined to a central area of the neoplasm.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/869fbb0d3c6e4215b998eefc79342689 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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