| Autor: |
Kruszewska Hanna, Zawistowska-Rojek Anna, Tyski Stefan |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Polish Journal of Microbiology, Vol 72, Iss 4, Pp 507-513 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2544-4646 |
| DOI: |
10.33073/pjm-2023-038 |
| Popis: |
Non-steroidal anti-inflammatory drugs (NSAIDs) commonly used in clinical practice may cause gastrointestinal injuries and influence the gut microbiota. This study investigated the effects of various NSAIDs and some analgesics on the viability of Lactobacillaceae strains (including probiotic strains) in vitro. It was found that diclofenac, ibuprofen, ketoprofen, dexketoprofen, flurbiprofen, and acetylsalicylic acid inhibited the growth of lactobacilli at a concentration of 0.05−3.2 mg/ml. These MICs of NSAIDs are well above therapeutic plasma concentrations achieved in humans, indicating that the tested drugs should not inhibit the growth of lactobacilli in the human digestive tract. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
