| Autor: |
Nosayba Al-Azzam, Lina Elsalem, Balqis M. Abu Mousa, Nesreen Saadeh |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
BIO Integration, Vol 5, Iss 1 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2712-0082 |
| DOI: |
10.15212/bioi-2024-0005 |
| Popis: |
Background: The relationships between uric acid levels, specific single nucleotide polymorphisms (SNPs) in genes linked to uric acid metabolism [xanthine dehydrogenase (XDH) and Solute carrier family 2 member 9 (SLC2A9) genes], and control of HbA1c levels in type 2 diabetes mellitus (T2DM) within the Jordanian population were determined. Methods: A total of 184 T2DM patients who received care in the Endocrine Clinic at KAUH in Northern Jordan were enrolled in this study. These patients were classified into controlled and uncontrolled T2DM groups based on the HbA1c test results. Genotyping of two SNPs from the SLC2A9 gene and one SNP related to the XDH gene was performed using the tetra ARMS PCR method. Uric acid concentrations were measured using enzymatic colorimetric reagents. Results: The study revealed no significant correlation between uric acid levels and T2DM control. However, statistically significant correlations (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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