Ameliorative effect of polydatin and polydatin-loaded chitosan nanoparticles against diabetes-induced pulmonary disorders in rats
Autor: | Fatma Mostafa, Sanaa R. Galaly, Hanaa M. Mohamed, Adel Abdel-Moneim, Manal Abdul-Hamid |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: | |
Zdroj: | Journal of Taibah University for Science, Vol 15, Iss 1, Pp 37-49 (2021) |
Druh dokumentu: | article |
ISSN: | 1658-3655 16583655 |
DOI: | 10.1080/16583655.2020.1860504 |
Popis: | The current study aims to evaluate the ameliorative effect of polydatin-loaded-chitosan nanoparticles (PD-CSNPs), polydatin (PD), and metformin on Diabetes-induced pulmonary disorders. After induction of diabetes, rats are classified into five groups, diabetic control and diabetic rats treated daily for four weeks with; PD, PD-CSNPs, chitosan-nanoparticles and metformin. Rats treated with PD and PD-CSNPs showed a reduction in glycosylated-haemoglobin % and lipid peroxidation level, increased activities of superoxide peroxidase, superoxide dismutase and catalase, and glutathione content in treated diabetic rats lung. Furthermore, PD-CSNPs, PD and MET decreased tumour necrosis factor-alpha and nuclear factor-kappa-β and upregulated nuclear factor erythroid 2-related factor-2 and haem oxygenase-1. Histological and ultrastructural examinations revealed their ameliorative effect via reducing the bronchiolar and alveolar fibrosis, thickening of the interalveolar septum, and inflammatory cell infiltration. In conclusion, PD-CSNPs was more effective than MET and PD in improvement the diabetes-induced pulmonary disorders through its antioxidant, anti-inflammatory, and prolonged-release properties. |
Databáze: | Directory of Open Access Journals |
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