Expression levels of MIF, NLRP1 and FOXP3 genes along with biomarker levels in patients with active form of non-segmental generalized vitiligo: A study in South Indian population

Autor: Alokananda Chakraborty, Seelamneni Thulasamma, Shravan Kumar Ghali, Priyanka Pallapolu, Kuna Lahari, Towseef Amin Rafeeqi, Gulam Mohammed Husain, Farhath Jabeen, Ghazala Javed, Mohammed Abdul Waheed, Munawwar Husain Kazmi
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Songklanakarin Journal of Science and Technology (SJST), Vol 44, Iss 2, Pp 353-360 (2022)
Druh dokumentu: article
ISSN: 0125-3395
DOI: 10.14456/sjst-psu.2022.50
Popis: Vitiligo, the most widespread hypopigmentary syndrome, is considered to be a multifactorial disease in which the active melanocytes are lost. Vitiligo has been studied in a variety of ways, and several genes have been implicated. In this study we focused on investigating biomarker levels of TNF-α, MDA and TAS by using ELISA, and along with that mRNA expression levels of MIF, NLRP1 and FoxP3 genes were quantified with qRT-PCR. In expression studies, Non-segmental Generalized Vitiligo (NSV) subjects had a substantial (P
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