Inflammatory markers and indicators of systemic endotoxemia in patients with treatment-resistant schizophrenia
| Autor: | S. A. Zozulya, I. N. Otman, I. A. Anikhovskaya, D. V. Tikhonov, V. G. Kaleda, M. Y. Yakovlev, T. P. Klyushnik |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | European Psychiatry, Vol 66, Pp S247-S248 (2023) |
| Druh dokumentu: | article |
| ISSN: | 0924-9338 1778-3585 |
| DOI: | 10.1192/j.eurpsy.2023.568 |
| Popis: | Introduction Elevated levels of lipopolysaccharide (LPS) in circulation support chronic inflammation, which is involved in the pathological process in the brain and may be a contributing factor to treatment resistance in schizophrenia. Objectives To compare inflammatory markers and indicators of systemic endotoxemia (SE) in patients with treatment-resistant schizophrenia and in those with a good response to treatment. Methods The study involved 34 patients with schizophrenia (27±7,5 years) (F20) in an acute psychotic state: 15 patients with TRS (non-responders), 19 patients responded to treatment with reduced symptoms (responders). The markers of systemic inflammation (leukocyte elastase (LE) and a1-proteinase inhibitor (α1-PI) activity, CRP concentration, antibodies (Abs) to S100B and myelin basic protein) and the indicators of SE (LPS level and Abs to LPS) were determined in the blood of patients. Results The responders showed a significant increase in LE and α1-P1 activity (p |
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