Lipid Droplet Accumulation and Impaired Fat Efflux in Polarized Hepatic Cells: Consequences of Ethanol Metabolism

Autor:	Benita L. McVicker, Karuna Rasineni, Dean J. Tuma, Mark A. McNiven, Carol A. Casey
Jazyk:	angličtina
Rok vydání:	2012
Předmět:	Diseases of the digestive system. Gastroenterology RC799-869
Zdroj:	International Journal of Hepatology, Vol 2012 (2012)
Druh dokumentu:	article
ISSN:	2090-3448 2090-3456
DOI:	10.1155/2012/978136
Popis:	Steatosis, an early manifestation in alcoholic liver disease, is associated with the accumulation of hepatocellular lipid droplets (LDs). However, the role ethanol metabolism has in LD formation and turnover remains undefined. Here, we assessed LD dynamics following ethanol and oleic acid treatment to ethanol-metabolizing WIF-B cells (a hybrid of human fibroblasts (WI 38) and Fao rat hepatoma cells). An OA dose-dependent increase in triglyceride and stained lipids was identified which doubled (P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/8680688a6f5945b087a9002254b0d268 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF