| Autor: |
Chiara Agrati, Concetta Castilletti, Delia Goletti, Alessandra Sacchi, Veronica Bordoni, Davide Mariotti, Stefania Notari, Giulia Matusali, Silvia Meschi, Linda Petrone, Alessandra Aiello, Saeid Najafi Fard, Chiara Farroni, Francesca Colavita, Daniele Lapa, Sara Leone, Alessandro Agresta, Maria Capobianchi, Giuseppe Ippolito, Francesco Vaia, Vincenzo Puro, INMI COVID-19 Vaccine Study Group |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 12, Iss 1, Pp 1-5 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-022-07741-z |
| Popis: |
Abstract Vaccine is the main public health measure to reduce SARS-CoV-2 transmission and hospitalization, and a massive scientific effort worldwide resulted in the rapid development of effective vaccines. This work aimed to define the dynamics and persistence of humoral and cell-mediated immune response in Health Care Workers who received a two-dose BNT162b2-mRNA vaccination. Serological response was evaluated by quantifying anti-RBD and neutralizing antibodies while cell-mediated response was performed by a whole blood test quantifying Th1 cytokines (IFN-γ, TNF-α, IL-2) produced in response to Spike peptides. BNT162b2-mRNA vaccine induced both humoral and cell-mediated immune response against Spike in all HCW early after the second dose. After 12 weeks from vaccination, the titer of anti-RBD antibodies as well as their neutralization function decreased while the Spike-specific T-cells persisted at the same level as soon after vaccine boost. Of note, a correlation between cellular and humoral response persevered, suggesting the persistence of a coordinated immune response. The long lasting cell-mediated immune response after 3 months from vaccination highlight its importance in the maintaining of specific immunity able to expand again to fight eventual new antigen encountering. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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