| Autor: |
Yukiko Ikeuchi-Yamamoto, Haruka Kogiso, Daichi Saito, Kotoku Kawaguchi, Riko Ikeda, Shinji Asano, Toshio Inui, Yoshinori Marunaka, Takashi Nakahari |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Phytomedicine Plus, Vol 2, Iss 2, Pp 100243- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2667-0313 |
| DOI: |
10.1016/j.phyplu.2022.100243 |
| Popis: |
Background: Hochu-ekki-to (TJ-41, a traditional herbal medicine) is used for preventing airway infections caused by viruss or bacterias in patients with chronic obstructive pulmonary disease (COPD). TJ-41 is known to inhibit viral adhesion and to activate mucosal immune system. However, the effects of TJ-41 on the beating cilia, which sweep away inhaled viruses and bacteria from the airways (mucociliary clearance, a host defense mechanism of lungs), still remain uncertain. Hypothesis/purpose: TJ-41 may activate the airway ciliary beating, activation of which increases the rate of mucociliary clearance leading to inhibit airway infections. Methods: TJ-41 was orally administered to mice for 4–8 weeks (1.7 - 1.8 g/kg/day) and airway ciliary cells were isolated from the lungs. The frequency (CBF) and angle (CBA, an index of amplitude) of ciliary beating were measured using the high-speed video microscopy (HSVM, 500 fps), in relation to intracellular Ca2+ concentration ([Ca2+]i). Differences were considered significant p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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