Nebulizer particle size distribution measured by various methods

Autor: Misik Ondrej, Peštálová Andrea, Belka Miloslav, Lízal Frantisek
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: EPJ Web of Conferences, Vol 264, p 01023 (2022)
Druh dokumentu: article
ISSN: 2100-014X
DOI: 10.1051/epjconf/202226401023
Popis: Pari LC Sprint Star nebulizer is an inhaler device dedicated to delivering the liquid drug formulation into peripheral lung regions. The particle size is one of the critical parameters which determine the location of aerosol deposition within the human lungs. In this study, the particle size distribution of aerosol was measured by two different methods: Andersen Cascade Impactor (ACI) and Aerodynamic Particle Sizer (APS). Mass Median of Aerodynamic Distribution (MMAD), and Geometric Standard Deviation (GSD) were evaluated. MMAD gained by APS was approx. 7 µm, MMAD acquired by ACI was approx. 2.5 µm. According to the results, these two measuring methods are not very consistent, and the comparison of the particle size acquired by the different methods is not appropriate.
Databáze: Directory of Open Access Journals