| Autor: |
Esther C. Gallegos-Cabriales, Ernesto Rodriguez-Ayala, Hugo A. Laviada-Molina, Edna J. Nava-Gonzalez, Rocío A. Salinas-Osornio, Lorena Orozco, Irene Leal-Berumen, Juan Carlos Castillo-Pineda, Laura Gonzalez-Lopez, Claudia Escudero-Lourdes, Judith Cornejo-Barrera, Fabiola Escalante-Araiza, Eira E. Huerta-Avila, Fatima A. Buenfil-Rello, Vanessa-Giselle Peschard, Eliud Silva, Rosa A. Veloz-Garza, Angelica Martinez-Hernandez, Francisco M. Barajas-Olmos, Fernanda Molina-Segui, Lucia Gonzalez-Ramirez, Ruy D. Arjona-Villicaña, Victor M. Hernandez-Escalante, Janeth F. Gaytan-Saucedo, Zoila Vaquera, Monica Acebo-Martinez, Areli Murillo-Ramirez, Sara P. Diaz-Tena, Benigno Figueroa-Nuñez, Melesio E. Valencia-Rendon, Rafael Garzon-Zamora, Juan Manuel Viveros-Paredes, Salvador B. Valdovinos-Chavez, Anthony G Comuzzie, Karin Haack, Ashley A. Thorsell, Xianlin Han, Shelley A. Cole, Raul A. Bastarrachea |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Biology, Vol 10, Iss 12, p 1342 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2079-7737 |
| DOI: |
10.3390/biology10121342 |
| Popis: |
We previously reported preliminary characterization of adipose tissue (AT) dysfunction through the adiponectin/leptin ratio (ALR) and fasting/postprandial (F/P) gene expression in subcutaneous (SQ) adipose tissue (AT) biopsies obtained from participants in the GEMM study, a precision medicine research project. Here we present integrative data replication of previous findings from an increased number of GEMM symptom-free (SF) adults (N = 124) to improve characterization of early biomarkers for cardiovascular (CV)/immunometabolic risk in SF adults with AT dysfunction. We achieved this goal by taking advantage of the rich set of GEMM F/P 5 h time course data and three tissue samples collected at the same time and frequency on each adult participant (F/P blood, biopsies of SQAT and skeletal muscle (SKM)). We classified them with the presence/absence of AT dysfunction: low (1) ALR. We also examined the presence of metabolically healthy (MH)/unhealthy (MUH) individuals through low-grade chronic subclinical inflammation (high sensitivity C-reactive protein (hsCRP)), whole body insulin sensitivity (Matsuda Index) and Metabolic Syndrome criteria in people with/without AT dysfunction. Molecular data directly measured from three tissues in a subset of participants allowed fine-scale multi-OMIC profiling of individual postprandial responses (RNA-seq in SKM and SQAT, miRNA from plasma exosomes and shotgun lipidomics in blood). Dynamic postprandial immunometabolic molecular endophenotypes were obtained to move towards a personalized, patient-defined medicine. This study offers an example of integrative translational research, which applies bench-to-bedside research to clinical medicine. Our F/P study design has the potential to characterize CV/immunometabolic early risk detection in support of precision medicine and discovery in SF individuals. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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