Effect of electroacupuncture on global cerebral ischemia‑reperfusion injury in rats: A urine proteome analysis

Autor:	Xiao Zhang, Yuting Dai, Fuguo Ma, Yuan Ma, Jiajia Wang, Xiaoxia Li, Weiwei Qin
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	cerebral ischemia‑reperfusion injury data‐independent acquisition electroacupuncture proteome Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Zdroj:	Brain and Behavior, Vol 14, Iss 1, Pp n/a-n/a (2024)
Druh dokumentu:	article
ISSN:	2162-3279
DOI:	10.1002/brb3.3382
Popis:	Abstract Background This study aimed to investigate dynamic urinary proteome changes of electroacupuncture (EP) on cerebral ischemia‑reperfusion (CI/R) injured rats and to explore the therapeutic biological mechanisms of EP. Methods First, changed urinary proteins were found in EP stimulation in healthy rats. Then, we used a CI/R injury rat model induced by Pulsinelli's four‐vessel occlusion (4‐VO) method to explore the function of EP on urinary proteome in CI/R injury. Urine samples were collected for proteome analysis by liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) and bioinformatics analysis. Results In total, 384 proteins were identified, among which 47 proteins (23 upregulated, 24 downregulated) were differentially expressed with 0.6‐log FC and p
Databáze:	Directory of Open Access Journals
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