Myeloid-Derived Suppressor Cells Participate in Preventing Graft Rejection

Autor:	Yan Wang, Xiaodong Gu, Jianbin Xiang, Zongyou Chen
Jazyk:	angličtina
Rok vydání:	2012
Předmět:	Immunologic diseases. Allergy RC581-607
Zdroj:	Clinical and Developmental Immunology, Vol 2012 (2012)
Druh dokumentu:	article
ISSN:	1740-2522 1740-2530
DOI:	10.1155/2012/731486
Popis:	Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells and have a tremendous potential to suppress immune responses. MDSCs accumulate during tumor progression, autoimmunity, chronic infection, transplantation, and other pathological conditions and can potently suppress T-cell function. Here, we discuss recent findings that describe the molecular mechanisms of MDSCs suppressing T-cell immune responses as well as recent observations that MDSCs may have roles in transplant tolerance.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/dce865ac614b43e2b9b646533d78e38d Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF