A Controlled Clinical Study of Accelerated High-Dose Theta Burst Stimulation in Patients with Obsessive–Compulsive Disorder

Autor: Jin Jiang, Ke Wan, Yueling Liu, Yan Tang, Wenxin Tang, Jian Liu, Jiehua Ma, Chuang Xue, Lu Chen, Huichang Qian, Dandan Liu, Xinxin Shen, Ruijuan Fan, Yongguang Wang, Kai Wang, Gongjun Ji, Chunyan Zhu
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Neural Plasticity, Vol 2023 (2023)
Druh dokumentu: article
ISSN: 1687-5443
DOI: 10.1155/2023/2741287
Popis: Background. Obsessive–compulsive disorder (OCD) is frequently treated using a combination of counseling, drugs, and, more recently various transcranial stimulation protocols, but all require several weeks to months for clinically significant improvement, so there is a need for treatments with faster onset. This study investigated whether an accelerated high-dose theta burst stimulation (ahTBS) protocol significantly improves the efficacy of OCD compared to traditional 1-Hz repetitive transcranial magnetic stimulation (rTMS) in the routine clinical setting. Method. Forty-five patients with OCD were randomized into two groups and treated with ahTBS or 1-Hz rTMS for 5 days. Patients were assessed at baseline at the end of treatment using the Yale–Brown Obsessive–Compulsive Scale (Y-BOCS). Results. After 5 days of treatment, there was a significant decrease in Y-BOCS scores in both groups (p
Databáze: Directory of Open Access Journals
Nepřihlášeným uživatelům se plný text nezobrazuje