Regenerative medicine for central nervous system disorders: Role of therapeutic molecules in stem cell therapy
| Autor: | Paola Suárez-Meade, Horacio G Carvajal, Takao Yasuhara, Naoki Tajiri, Isao Date, Cesario V Borlongan |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Brain Circulation, Vol 1, Iss 2, Pp 125-132 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2455-4626 2394-8108 |
| DOI: | 10.4103/2394-8108.172884 |
| Popis: | The efficacy of stem cell therapy is greatly influenced by their secretory properties. Evidence suggests that there is a high concentration of growth factors such as brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), and glial cell line-derived neurotrophic factor (GDNF) after stem cell transplantation. Also, the presence of therapeutic molecules and cytokines such as stem cell factor (SCF), stromal cell-derived factor-1α (SDF-1α), RNAs, nuclear enriched abundant transcript 1 (NEAT1), and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is consistent throughout several studies. Apart from modulating the homeostasis of the surrounding tissues, these factors have pleiotropic properties over the host tissue, among which are angiogenic, anti-inflammatory, antiapoptotic, and neurogenic effects. In the present manuscript, we discuss the different secretion factors and their beneficial activity after stem cell transplantation. Recent developments in emerging technologies for coadjunctive therapies that may aid in stem cell transplantation into the central nervous system, such as cell encapsulation, molecular Trojan horses, and viral vectors, are also presented in this article. |
| Databáze: | Directory of Open Access Journals |
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