A Randomized, Controlled, Parallel-Group, Trial on the Long-term Effects of Melatonin on Fatigue Associated With Breast Cancer and Its Adjuvant Treatments
| Autor: | Abdolazim Sedighi Pashaki MD, Fateme Sheida MD, Leila Moaddab Shoar MD, Tahereh Hashem MD, Danial Fazilat-Panah, Alireza Nemati Motehaver MD, Ali Ghanbari Motlagh MD, Safoora Nikzad PhD, Mojtaba Bakhtiari MD, Leili Tapak PhD, Zahir Keshtpour Amlashi MD, Seyed Alireza Javadinia MD, Zahra Keshtpour Amlashi MD |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Integrative Cancer Therapies, Vol 22 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1552-695X 15347354 |
| DOI: | 10.1177/15347354231168624 |
| Popis: | Objective: Cancer related fatigue is a distressing condition and correlated with decrease in quality of life of patients with malignant conditions. In continuation of our previous research, we assessed long term anti-fatigue effects of melatonin in patients with the breast cancer. Material and methods: In this clinical trial, 92 breast cancer patients were randomly assigned to receive either melatonin (18 mg/day) or placebo from 1 week before the adjuvant treatments until 2 years after their completion. The levels of fatigue were assessed before and after intervention using Brief Fatigue Inventory (BFI) and were compared at a significance level of P ≤ .05. Results: The BFI scores were similar between the 2 groups at the baseline (placebo group: 5.56 ± 1.59 and melatonin group: 5.72 ± 1.68, P = .67). After the intervention, not only the mean fatigue score was significantly lower in melatonin group (2.93 ± 1.04 vs 1.99 ± 1.02, P |
| Databáze: | Directory of Open Access Journals |
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