Diffuse large B-cell lymphoma: a single disease?
| Autor: | Paulo Castañeda-Ruiz, Fanny Via y Rada, Rebeca Serra-Jaramillo, Eduardo Paz-Cornejo, Fernando Salas-Sánchez |
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| Jazyk: | Spanish; Castilian |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Revista Peruana de Medicina Experimental y Salud Pública, Vol 34, Iss 3, Pp 551-9 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1726-4634 1726-4642 |
| DOI: | 10.17843/rpmesp.2017.343.2803 |
| Popis: | Non-Hodgkin’s lymphomas are common and comprise a heterogeneous group of neoplasms, with diffuse large B-cell lymphoma (DLBCL) accounting for more than 60% of cases. Moreover, DLBCL presents with a variety of clinical characteristics, genetic profiles, and therapeutic responses. We aimed to improve progression-free survival, total survival, and objective results in an DLBCL subgroup. However, another subgroup demonstrated poor responses. Therefore, it is necessary to design treatment programs based on clinical, immunohistochemical, and genetic profiles, grouping cases properly to identify correct therapeutic modalities for each lymphoma subtype. Currently, these neoplasms are classified as high- and low-risk lymphomas, and therapeutic regimens are being developed to complement conventional R-CHOP, such as R-DA-EPOCH, R2CHOP, IR-CHOP, VR-CHOP, and eveRCHOP, which are expected to improve outcomes. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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