| Autor: |
Christopher A. Preston, Eric X. Z. Yong, Benjamin Marginson, Stephen G. Farrell, Matthew P. Sawyer, Hikaru Hashimura, Maresa M. Derbyshire, Richard J. MacIsaac, Nirupa Sachithanandan |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Endocrinology, Diabetes & Metabolism, Vol 7, Iss 5, Pp n/a-n/a (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2398-9238 |
| DOI: |
10.1002/edm2.70001 |
| Popis: |
ABSTRACT Background Adrenal vein sampling (AVS), integral to identifying surgically remediable unilateral primary aldosteronism (PA), is technically challenging and subject to fluctuations in cortisol and aldosterone secretion. Intra‐procedural adrenocorticotropic hormone (ACTH), conventionally administered as a 250‐μg bolus and/or 50 μg per hour infusion, increases cortisol and aldosterone secretion and can improve AVS success, but may cause discordant lateralisation compared to unstimulated AVS. Aims To assess if AVS performed with ultra‐low dose ACTH infusion causes discordant lateralisation. Methods Here, we describe our preliminary experience using an ultra‐low dose ACTH infusion AVS protocol. We retrospectively reviewed the results of consecutive AVS procedures (n = 37) performed with and without ultra‐low dose ACTH (1‐μg bolus followed by 1.25 μg per hour infusion). Results Bilateral AV cannulation was successful in 70% of procedures pre‐ACTH and 89% post‐ACTH (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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