| Autor: |
Chiu Wang Chau, Alex To, Rex K. H. Au-Yeung, Kaiming Tang, Yang Xiang, Degong Ruan, Lanlan Zhang, Hera Wong, Shihui Zhang, Man Ting Au, Seok Chung, Euijeong Song, Dong-Hee Choi, Pentao Liu, Shuofeng Yuan, Chunyi Wen, Ryohichi Sugimura |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-024-59405-9 |
| Popis: |
Abstract SARS-CoV-2 provokes devastating tissue damage by cytokine release syndrome and leads to multi-organ failure. Modeling the process of immune cell activation and subsequent tissue damage is a significant task. Organoids from human tissues advanced our understanding of SARS-CoV-2 infection mechanisms though, they are missing crucial components: immune cells and endothelial cells. This study aims to generate organoids with these components. We established vascular immune organoids from human pluripotent stem cells and examined the effect of SARS-CoV-2 infection. We demonstrated that infections activated inflammatory macrophages. Notably, the upregulation of interferon signaling supports macrophages’ role in cytokine release syndrome. We propose vascular immune organoids are a useful platform to model and discover factors that ameliorate SARS-CoV-2-mediated cytokine release syndrome. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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