Nationwide cohort observational study on the safety and efficacy of COVID-19 vaccination in patients with moyamoya disease

Autor:	Hyoung Soo Byoun, Si Un Lee, Yu Deok Won, Tae Won Choi, Sang Hyo Lee, Young-Deok Kim, Seung Pil Ban, Jae Seung Bang, O-Ki Kwon, Chang Wan Oh
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Coronavirus disease Moyamoya disease Stroke Vaccination Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-73940-5
Popis:	Abstract The safety and efficacy of coronavirus disease 2019 (COVID-19) vaccination in patients diagnosed with Moyamoya disease (MMD) have not been established. Using National Health Insurance Service data, this study analyzed the occurrence of stroke-related events and mortality following COVID-19 vaccination among patients diagnosed with MMD from 2008 to 2020. Among 10,297 MMD patients, 296 (2.9%) experienced events and 175 (1.7%) died in 2021. Significant risk factors for events included ages 50–59 (Odds Ratio [OR] 3.29; P = 0.022) and 60 or above (OR 5.20; P = 0.001) (reference group: age in 20s), low BMI (OR 2.00; P = 0.011), previous stroke (OR 1.96; P
Databáze:	Directory of Open Access Journals
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