| Autor: |
Cecilia Catellani, Gloria Ravegnini, Chiara Sartori, Beatrice Righi, Pietro Lazzeroni, Laura Bonvicini, Silvia Poluzzi, Francesca Cirillo, Barbara Predieri, Lorenzo Iughetti, Paolo Giorgi Rossi, Sabrina Angelini, Maria Elisabeth Street |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Frontiers in Endocrinology, Vol 13 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1664-2392 |
| DOI: |
10.3389/fendo.2022.896640 |
| Popis: |
ContextThere is growing evidence of the role of epigenetic regulation of growth, and miRNAs potentially play a role.ObjectiveThe aim of this study is to identify changes in circulating miRNAs following GH treatment in subjects with isolated idiopathic GH deficiency (IIGHD) after the first 3 months of treatment, and verify whether these early changes can predict growth response.Design and MethodsThe expression profiles of 384 miRNAs were analyzed in serum in 10 prepubertal patients with IIGHD (5 M, 5 F) at two time points before starting GH treatment (t−3, t0), and at 3 months on treatment (t+3). MiRNAs with a fold change (FC) >+1.5 or |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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