Long-term statins administration exacerbates diabetic nephropathy via ectopic fat deposition in diabetic mice

Autor: Tong-sheng Huang, Teng Wu, Yan-di Wu, Xing-hui Li, Jing Tan, Cong-hui Shen, Shi-jie Xiong, Zi-qi Feng, Sai-fei Gao, Hui Li, Wei-bin Cai
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-023-35944-z
Popis: Huang et al. investigated the effects of long-term statins administration in a mouse model for diabetes and found that it can worsen insulin resistance, renal inflammation and fibrosis. Statins increased renal lipid uptake and inhibited fatty acid oxidation, contributing to diabetic nephropathy.
Databáze: Directory of Open Access Journals