Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations
| Autor: | Todd A. Koch, Jennifer Myers, Lawrence Tim Goodnough |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Anemia, Vol 2015 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2090-1267 2090-1275 |
| DOI: | 10.1155/2015/763576 |
| Popis: | Objective. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. Methods. We first individually analyzed 5 clinical studies, averaging the total iron deficit across all patients utilizing a modified Ganzoni formula; we then similarly analyzed 2 larger clinical studies. For the second of the larger studies (Study 7), we also compared the efficacy and retreatment requirements of a cumulative dose of 1500 mg ferric carboxymaltose (FCM) to 1000 mg iron sucrose (IS). Results. The average iron deficit was calculated to be 1531 mg for patients in Studies 1–5 and 1392 mg for patients in Studies 6-7. The percentage of patients who were retreated with IV iron between Days 56 and 90 was significantly (p |
| Databáze: | Directory of Open Access Journals |
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