Synthesis of 6β-N(5)-Methyl-5,6,7,8-tetrahydro-L-biopterin

Autor:	Bosshard Rene, Heizmann Claus W., Viscontini Max
Jazyk:	angličtina
Rok vydání:	1993
Předmět:	6β-n(5)-methyl-5 6 7.8-tetrahydro-l-biopterin catalytic reductive methylation 6β-5 6 7 8-tetrahydrol- biopterin 6β)-5 6j 8-tetrahydro-l-biopterin l-biopterin. n(5)-methyl-5.6.7.8-tetrahydro-pterin hyperphenylalaninemia phenylketonuria Crystallography QD901-999
Zdroj:	Pteridines, Vol 4, Iss 3, Pp 115-118 (1993)
Druh dokumentu:	article
ISSN:	0933-4807 2195-4720
DOI:	10.1515/pteridines.1993.4.3.115
Popis:	Summary 6β-N(5)-methyl-5.6J,8-tetrahydro-L-biopterin·2 HC1. a new derivate of biological interest, was synthesized from 6β-5,6,7,8-tetrahydro-L-biopteril·2 HC1 and characterized. The latter compound has been used therapeutically in atypical phenylketonuria for many years. The catalytic reductive methylation with PtO2 /H2 and formaldehyde allowed selective methylation at the N(5) position. The chemical properties and stnlctures of the new compound arc compared with N(5)-methyl-tetrahydropterin and N(5)-methyl-tetrahydrofolate.
Databáze:	Directory of Open Access Journals
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