| Autor: |
Maria Soares, Catarina Freitas, Maria Helena Timoteo, Ana Patrícia Lourenço, Ana Ferreira, João Paulo Figueiredo, Telmo Pereira, Armando Caseiro |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Journal of Vascular Diseases, Vol 3, Iss 3, Pp 333-341 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2813-2475 |
| DOI: |
10.3390/jvd3030026 |
| Popis: |
Aging is a complex process inherent to and inevitable in humans. With life expectancy rising, there are concerns about the senior population’s wellbeing, and a hope of preventing certain diseases such as cardiovascular diseases. To achieve it, this study resorts to the implementation of an interventional program based on the comprehensive geriatric assessment model [AGA@4life]. The aim is to evaluate the effect of a new nutritional and exercise regime and evaluate possible changes in nitric oxide (NO) metabolites and endothelin 1 (ET-1). An intervention study was developed with 17 participants with ages of 65 and above. They were evaluated in the beginning [T0] and after eight weeks [T1], where NO metabolites and ET-1 levels were determined by enzymatic assays and the slot blot technique, respectively. There was a significant decrease in ET-1 levels in both the control (p < 0.001) and intervention (p = 0.04) groups from T0 to T1, but there was only a tendency for a decrease in the NO metabolite’s levels in the same conditions [p > 0.05]. Even though the NO metabolite levels did not increase as expected, possibly because of an increase in oxidative stress, the ET-1 levels decreased as expected and the overall results are promising, proving this program could have a beneficial effect on the geriatric population. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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