Behavioral investigation of mice with experimental autoimmune encephalomyelitis
| Autor: | David Henrique Rodrigues, Márcia de Carvalho Vilela, Norinne Lacerda-Queiroz, Aline Silva de Miranda, Larissa Fonseca da Cunha Sousa, Helton José dos Reis, Antônio Lúcio Teixeira |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Arquivos de Neuro-Psiquiatria, Vol 69, Iss 6, Pp 938-942 (2011) |
| Druh dokumentu: | article |
| ISSN: | 1678-4227 0004-282X |
| DOI: | 10.1590/S0004-282X2011000700018 |
| Popis: | Multiple sclerosis is a neuroinflammatory disease that results in serious neurological disability. Besides physical impairment, behavioral symptoms are also common in patients with multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) is considered to be a model of multiple sclerosis and mimics the main features of the disease, such as demyelination and motor impairment. In this work, we aimed to study behavioral parameters in animals with EAE using the MOG35-55 model in C57BL/6 mice. We analyzed memory and anxiety in animals using the elevated plus maze, the step down inhibitory avoidance task and the memory recognition test. No differences in any tests were found when comparing controls and animals induced with EAE. Therefore, we conclude that behavioral changes in animals with EAE induced with MOG35-55 are probably subtle or absent. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|